반응 #40917

반응 방정식

diethyl ether

4-oxo-cyclohexanecarboxylic acid ethyl ester

ethylene glycol

p-toluenesulfonic acid

→

1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

용매

toluene

반응 조건

후처리

1. 1
   세척washed with water, sodium hydrogen carbonate solution and sodium chloride solution
2. 2
   건조The solution was dried (Na2SO4)
3. 3
   농축concentrated by evaporation in vacuo
4. 4
   기타the remaining colorless liquid was processed further without purification

실험 절차

4-oxo-cyclohexanecarboxylic acid ethyl ester (52.8 g, 0.31 mole, Merck, Order No. 814249), ethylene glycol (67.4 g, 1.08 mole) and p-toluenesulfonic acid (0.7 g) in toluene (160 ml) were stirred for 20 hours at RT, and the reaction solution was poured into diethyl ether (300 ml) and washed with water, sodium hydrogen carbonate solution and sodium chloride solution. The solution was dried (Na2SO4), concentrated by evaporation in vacuo, and the remaining colorless liquid was processed further without purification.

출처