반응 #40894

반응 방정식

7-bromoindole

dichloromethane

aluminum chloride

succinic acid monoethyl ester chloride

→

titled compound

ethyl 4-(7-bromo-1H-indol-3-yl)-4-oxobutanoate

용매

ethyl acetate

반응 조건

후처리

1. 1
   workup.STIRRINGby stirring at room temperature for 5 hours
2. 2
   추출followed by extraction with ethyl acetate
3. 3
   세척The organic layer was washed in turn with water and saturated saline
4. 4
   건조dried over anhydrous sodium sulfate
5. 5
   농축concentrated
6. 6
   세척The residue was washed with diisopropyl ether

실험 절차

To a dichloromethane (50 mL) solution of aluminum chloride (6.80 g), succinic acid monoethyl ester chloride (8.39 g) was added under ice cooling and the mixture was stirred for 30 minutes. To the mixture, 7-bromoindole (5.0 g) was added, followed by stirring at room temperature for 5 hours. To the reaction mixture, ice water and ethyl acetate were added, followed by extraction with ethyl acetate. The organic layer was washed in turn with water and saturated saline, dried over anhydrous sodium sulfate and then concentrated. The residue was washed with diisopropyl ether to obtain the titled compound having the following physical properties (6.04 g).

출처