반응 #40848

반응 방정식

(Z)-3-hydroxy-2,3-diphenyl-propenal

(Z)-3-Hydroxy-2,3-diphenyl-propenal

pTSA

methyl urea

diethyl ether

→

title compound

1-Methyl-5,6-diphenyl-1H-pyrimidin-2-one

용매

CH2Cl2

toluene

반응 조건

후처리

1. 1
   기타The reaction was quenched with water
2. 2
   추출the products were extracted with ethyl acetate
3. 3
   기타The organic layer was separated
4. 4
   세척washed with brine
5. 5
   건조dried over MgSO4
6. 6
   농축concentrated in vacuo
7. 7
   기타to produce a yellow oil

실험 절차

A solution of (Z)-3-hydroxy-2,3-diphenyl-propenal (105, 423 mg, 1.89 mmol), pTSA (30 mg, 7.56 mmol) and methyl urea (118 mg, 0.62 mmol) in toluene was heated at 110° C. overnight. The reaction was quenched with water, and the products were extracted with ethyl acetate. The organic layer was separated and washed with brine, and dried over MgSO4, and concentrated in vacuo to produce a yellow oil. The crude product was dissolved in CH2Cl2 and titrated with diethyl ether to give the title compound as a white solid.

출처