반응 #40824

반응 방정식

5,6-diphenylpyridine-2-carbaldehyde

Compound 54

5,6-diphenylpyridine-2-carbaldehyde

(3-amino-propyl)-phosphonic acid

NaCNBH3

→

title compound

{3-[(5,6-Diphenylpyridin-2-ylmethyl)-amino]-propyl}-phosphonic Acid

용매

MeOH

MeOH

반응 조건

후처리

1. 1
   workup.STIRRINGThe solution was stirred at 50° C. for 3 hours
2. 2
   농축it was concentrated in vacuo
3. 3
   기타The resulting crude solid was purified MPLC column chromatography (silica gel, 0-100% MeOH in ethyl acetate)

실험 절차

General Procedure M. To a solution of 5,6-diphenylpyridine-2-carbaldehyde (Compound 54, 95 mg, 0.37 mmol) and (3-amino-propyl)-phosphonic acid (51 mg, 0.37 mmol) in MeOH (3 ml) was added Bu4NOH (0.4 ml, 0.37 mmol, 1M in MeOH) under argon. The mixture was stirred at 50° C. for 30 min. before adding NaCNBH3 (23 mg, 0.37 mmol) to the mixture. The solution was stirred at 50° C. for 3 hours, and then it was concentrated in vacuo. The resulting crude solid was purified MPLC column chromatography (silica gel, 0-100% MeOH in ethyl acetate) to obtain the title compound as a white solid.

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