반응 #40819

ord-2678073f777c403da66620f9ff443181

반응 방정식

CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-(4-ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccc(C(F)(F)F)cc2)n1
Compound 48
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-(4-ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate
→
CCc1ccc(-c2ccc(C(=O)OC)nc2-c2ccc(C(F)(F)F)cc2)cc1
title compound
CCc1ccc(-c2ccc(C(=O)OC)nc2-c2ccc(C(F)(F)F)cc2)cc1
Methyl 5-(4-Ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate

반응물

CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-(4-ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccc(C(F)(F)F)cc2)n1
Compound 48
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-(4-ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate

시약

O=S(=O)(O)O
H2SO4

용매

CO
methanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타were reacted

실험 절차

Following General Procedure E, ethyl 5-(4-ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate (Compound 48, 60 mg, 0.15 mmol) and conc. H2SO4 (10 drops) in methanol were reacted to produce the title compound as a light yellow solid.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07728014B2uspto-grants-2010_06