반응 #40743

반응 방정식

THF

5-Chloro-3-ethyl-2-naphthalen-1-yl-3H-imidazole-4-carboxylic acid ethyl ester

THF

lithium hydroxide

→

title compound

5-chloro-3-ethyl-2-naphthalen-1-yl-3H-imidazole-4-carboxylic acid

용매

water

반응 조건

후처리

1. 1
   기타The solid precipitate is collected
2. 2
   세척washed with water and ether
3. 3
   기타dried under high vacuum

실험 절차

5-Chloro-3-ethyl-2-naphthalen-1-yl-3H-imidazole-4-carboxylic acid ethyl ester (62 g, 35 mmol) is dissolved in. THF (10 ml), and aqueous lithium hydroxide solution (2.0 N, 6.35 ml, 2.0 eq.) is added. The mixture is heated at 50° C. overnight. THF is stripped off under reduced pressure, and the residue is diluted with water (10 ml) and basified to pH=4=5. The solid precipitate is collected, washed with water and ether, and dried under high vacuum to give the title compound. LCMS 301 (M+1).

출처