반응 #4072

반응 방정식

(S)-2-(5-chloro-6-methoxy-2-naphthyl)-propionic acid

→

(S)-2-(6-methoxy-2-naphthyl)propionic acid

용매

sodium hydroxide

반응 조건

후처리

1. 1
   여과it is filtered
2. 2
   workup.ADDITIONdiluted with excess dilute hydrochloric acid
3. 3
   추출extracted with methylene chloride
4. 4
   기타The organic phase is evaporated to dryness
5. 5
   기타the residue recrystallized from methylene chloride/hexane

실험 절차

A solution of 1 g of (S)-2-(5-chloro-6-methoxy-2-naphthyl)-propionic acid in 20 ml of 10% aqueous sodium hydroxide solution at 90° C. is treated with 3 g of a nickel-aluminum alloy in small portions. After stirring the mixture for two hours, it is filtered, diluted with excess dilute hydrochloric acid and extracted with methylene chloride. The organic phase is evaporated to dryness and the residue recrystallized from methylene chloride/hexane to yield (S)-2-(6-methoxy-2-naphthyl)propionic acid after recrystallization.

출처