반응 #40717

반응 방정식

1-Azido-5-chloro-2,4-dimethoxy-benzene

3-(4-Fluoro-phenyl)-3-oxo-propionic acid methyl ester

sodium ethoxide

→

1-(5-Chloro-2,4-dimethoxy-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid

용매

EtOH

반응 조건

후처리

1. 1
   기타During the reaction
2. 2
   기타After that, EtOH was evaporated off
3. 3
   기타the resulting oil was dried in vacuum
4. 4
   기타Trituration with ether (15 mL) gave light brown solids, which
5. 5
   기타were removed by filtration
6. 6
   세척washed with ether
7. 7
   workup.DISSOLUTIONThe solids then re-dissolved in CHCl3
8. 8
   여과filtered
9. 9
   기타After evaporation of the solvent
10. 10
    기타light brown solids were obtained (0.35 g, 50%)

실험 절차

1-Azido-5-chloro-2,4-dimethoxy-benzene (0.4 g, 1.9 mmol), 3-(4-Fluoro-phenyl)-3-oxo-propionic acid methyl ester (0.42 g, 2.2 mmol) and sodium ethoxide in EtOH (70 mg of sodium in 15 mL EtOH) were refluxed for 3 hours. During the reaction, the solution turned brown from dark green. After that, EtOH was evaporated off and the resulting oil was dried in vacuum. Trituration with ether (15 mL) gave light brown solids, which were removed by filtration and washed with ether. The solids then re-dissolved in CHCl3 and filtered. After evaporation of the solvent, light brown solids were obtained (0.35 g, 50%).

출처