반응 #40662

반응 방정식

1d

2-(4,4-Dimethyl-3,4-dihydro-2H-quinolin-1-yl)-phenylamine

benzoyl isothiocyanate

→

1-benzoyl-3-(2-(4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl)phenyl)thiourea

용매

CH2Cl2

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   기타the solvent was evaporated
3. 3
   건조The resulting crude 1e was dried over vacuum

실험 절차

1d (65.4 mg, mmol) and benzoyl isothiocyanate (60 mg) were heated at refluxing CH2Cl2 for 2 h. After cooling, the solvent was evaporated. The resulting crude 1e was dried over vacuum and used directly in the next step: LC-MS ESI, 416.3 (M+H) (10-90% MeOH in H2O with 0.1% TFA in a 4 min run, tR=4.49 min).

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