반응 #40626

반응 방정식

Cyclohexylamine

3-chloro-propionic acid ethyl ester

K2CO3

→

title compound

수율 72.3%

3-Cyclohexylamino-propionic acid ethyl ester

수율 72.3%

반응 조건

후처리

1. 1
   기타The resulting mixture was then partitioned between water and dichloromethane
2. 2
   건조The organic layer was dried (MgSO4)
3. 3
   농축concentrated

실험 절차

Cyclohexylamine (0.86 g, 8.7 mmol) and 3-chloro-propionic acid ethyl ester (1.18 g, 8.67 mmol) were combined neat and K2CO3 (1.2 g, 8.7 mmol) and a catalytic amount of tetrabutylammonium iodide (ca. 5 mg) was added. The mixture was heated at 80° C. overnight. The resulting mixture was then partitioned between water and dichloromethane. The organic layer was dried (MgSO4) and concentrated to afford 1.25 g (72%) of the title compound.

출처