반응 #40576

반응 방정식

4-Chlorophenylacetic acid

hydrogen chloride methanol

→

methyl 2-(4-chlorophenyl)acetate

반응 조건

후처리

1. 1
   온도heated under reflex for 14 hours
2. 2
   기타The solvent then was removed under reduced pressure and saturated sodium hydrogencarbonate solution
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   추출followed by extraction with ethyl acetate
5. 5
   건조The organic layer was dried over anhydrous sodium sulfate and condensed under reduced pressure

실험 절차

4-Chlorophenylacetic acid (5.0 g) was dissolved in 10% hydrogen chloride-methanol solution (50 ml) and heated under reflex for 14 hours. The solvent then was removed under reduced pressure and saturated sodium hydrogencarbonate solution was added to the residue, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and condensed under reduced pressure to provide methyl 2-(4-chlorophenyl)acetate (5.35 g) as a colorless, oily substance.

출처