반응 #40531

반응 방정식

2-amino-3-nitro-benzoic acid methyl ester

bromine

→

title compound

수율 87.4%

2-Amino-5-bromo-3-nitro-benzoic acid methyl ester

수율 87.4%

용매

acetic acid

acetic acid

반응 조건

후처리

1. 1
   여과The precipitated yellow solid was collected by suction filtration
2. 2
   기타dried

실험 절차

To a solution of 2.23 g (10.4 mmol) of 2-amino-3-nitro-benzoic acid methyl ester in 12 mL of acetic acid was added dropwise over 5 minutes a solution of 0.53 mL (10.4 mmol, 1 eq) of bromine in 2 mL of acetic acid. The mixture was stirred at room temperature for 30 minutes and poured into 100 grams of ice. The precipitated yellow solid was collected by suction filtration and dried to afford 2.50 g (82%) of the title compound as a yellow solid. 1H NMR (CDCl3) δ 3.95 (s, 3H), 8.35 (br s, 2H), 8.6 (d, 1H).

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