반응 #40491

반응 방정식

N-(6-chloro-9H-β-carbolin-4-yl)-2,2,2-trifluoro-acetamide

NaNO2

→

N-(6-chloro-8-nitro-9H-β-carbolin-4-yl)-2,2,2-trifluoro-acetamide

수율 92.0%

용매

TFA

반응 조건

후처리

1. 1
   기타Volatiles were removed by rotovap
2. 2
   여과filtered

실험 절차

N-(6-chloro-9H-β-carbolin-4-yl)-2,2,2-trifluoro-acetamide (125 mg, 0.4 mmol, 1 equiv.) was dissolved in 2 ml TFA and NaNO2 (541 mg, 7.84 mmol, 2 equiv.) was added in one portion. The solution was stirred at room temperature for 4 hr. Volatiles were removed by rotovap, and the resulting oily orange solids were suspended in water, neutralized with a saturated aqueous sodium bicarbonate solution and filtered to give 132 mg (92%) of N-(6-chloro-8-nitro-9H-β-carbolin-4-yl)-2,2,2-trifluoro-acetamide.

출처