반응 #40460
ord-43669270af0443af8dcc4c27264a3edb
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출The aqueous solution was extracted (3×) with EtOAc
- 2건조The combined EtOAc layers were dried
- 3기타evaporated
- 4기타The crude product was purified by flash chromatography
실험 절차
Sodium ethoxide (232 mg, 3.4 mmol) was added to a solution of 6-chloro-7-fluoro-8-nitro-9H-β-carboline (200 mg, 0.76 mmol) in DMSO (4 ml) and the reaction mixture allowed to stir overnight. The reaction mixture was diluted with water and the pH of the solution was adjusted to about 4 by adding 1N HCl. The aqueous solution was extracted (3×) with EtOAc. The combined EtOAc layers were dried and evaporated. The crude product was purified by flash chromatography to give the desired product in 40-60% yield.