반응 #40458

반응 방정식

6-chloro-7-methoxy-9H-β-carbolin-8-ylamine

EDCI

2-methyl nicotinic acid

→

desired product

수율 50.0%

N-(6-chloro-7-methoxy-9H-β-carbolin-8-yl)-2-methyl-nicotinamide

수율 50.0%

용매

pyridine

반응 조건

후처리

1. 1
   기타The pyridine was then removed by rotary evaporation and 5% Na2CO3 solution
2. 2
   workup.ADDITIONwas added
3. 3
   기타The resulting solid that precipitated out
4. 4
   여과was collected by filtration
5. 5
   기타Chromatographic purification

실험 절차

6-chloro-7-methoxy-9H-β-carbolin-8-ylamine (100 mg, 0.4 mmol), EDCI (125 mg, 0.64 mmol) and 2-methyl nicotinic acid (66 mg, 0.48 mmol) were taken in a round-bottom flask and suspended in pyridine (2 ml). The resulting mixture was heated at 80° C. overnight. The pyridine was then removed by rotary evaporation and 5% Na2CO3 solution was added. The resulting solid that precipitated out was collected by filtration. Chromatographic purification gave the desired product in 50-70% yield.

출처