반응 #40427

반응 방정식

2-nitrobenzoyl chloride

2-amino-5-bromopyridine

pyridine

→

N-(5-bromo-2-pyridinyl)-(2-nitro)phenylcarboxamide

수율 77.9%

용매

methylene chloride

반응 조건

후처리

1. 1
   기타The volatile was evaporated

실험 절차

A solution of 2-nitrobenzoyl chloride (3.70 g, 20 mmol, 1.0 equiv), 2-amino-5-bromopyridine (3.50 g, 1.0 equiv), pyridine (10 mL) in 25 mL of methylene chloride was stirred overnight. The volatile was evaporated, flash chromatography on silica gel gave N-(5-bromo-2-pyridinyl)-(2-nitro)phenylcarboxamide (5.02 g, 77%). MS found for C12H9BrN3O3 (M+H)+: 322.

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