반응 #40424

반응 방정식

citraconic anhydride

2-amino-5-bromopyridine

→

solid

수율 71.0%

N-(5-bromopyridin-2-yl)-methylmaleimide

수율 71.0%

용매

toluene

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도to reflux overnight
3. 3
   온도The solution was cooled down
4. 4
   여과filtered
5. 5
   농축The filtrate was concentrated in vacuo

실험 절차

A mixture of citraconic anhydride (1.00 mL, 11.1 mmol) and 2-amino-5-bromopyridine (1.93 g, 11.2 mmol) in toluene (60 mL) was heated to reflux overnight. The solution was cooled down, filtered. The filtrate was concentrated in vacuo to give a solid (2.10 g, yield: 71%). MS 267 and 269 (M+H).

출처