반응 #40419

반응 방정식

N-(5-chloro(2-pyridyl)){6-[(4-cyanophenyl)-carbonylamino]-3-hydroxyphenyl}carboxamide

Cs2CO3

ethyl bromoacetate

→

crude compound

수율 112.4%

ethyl 2-{3-[N-(5-chloro(2-pyridyl))carbamoyl]-4-[(4-cyanophenyl)carbonylamino]-phenoxy}acetate

수율 112.4%

용매

DMF

EtOAc

water

반응 조건

후처리

1. 1
   세척The organic layer was washed with brine
2. 2
   기타dried
3. 3
   기타evaporated

실험 절차

To a mixture of compound N-(5-chloro(2-pyridyl)){6-[(4-cyanophenyl)-carbonylamino]-3-hydroxyphenyl}carboxamide (50 mg, 0.13 mmol) and Cs2CO3 (83 mg, 0.25 mmol) in DMF (1 mL) at room temperature was added ethyl bromoacetate (15 μL, 0.13 mmol). The mixture was stirred for 1 hour before diluted with EtOAc (20 mL) and water (10 mL). The organic layer was washed with brine dried and evaporated to give 70 mg of the crude compound, which was used without further purification. MS found for C24H19ClN4O3 (M+H)+: 479.0.

출처