반응 #40340

반응 방정식

caustic soda

1-bromohexane

N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine

caesium carbonate

→

title compound

N-(5-hexyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine

용매

dimethylformamide

반응 조건

후처리

1. 1
   추출is extracted with ethyl acetate
2. 2
   건조the combined organic phases are dried over sodium sulphate
3. 3
   농축concentrated by evaporation

실험 절차

1-bromohexane (0.11 mmol) is added to a suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine (0.1 mmol) and caesium carbonate (0.22 mmol) in dimethylformamide (0.3 ml) and the reaction mixture is stirred overnight at room temperature. After adding 2M caustic soda solution (1 ml) the mixture is extracted with ethyl acetate, the combined organic phases are dried over sodium sulphate and then concentrated by evaporation, the title compound being obtained in pure form.

출처