반응 #40333
ord-9141ed1670cb49bcba55b96621509c0b
반응 방정식
water
N-bromosuccinimide
sodium acetate
trimethyl-(3-methyl-cyclohex-1-enyloxy)-silane
→
title compound
2-bromo-3-methyl-cyclohexanone
반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
A solution of N-bromosuccinimide (0.48 mmol) and sodium acetate (0.04 mmol) in THF/water (1:1, 5.2 ml) is cooled to 0° C. and trimethyl-(3-methyl-cyclohex-1-enyloxy)-silane (0.4 mmol, 80% pure) is added dropwise. The reaction mixture is heated to room temperature and stirring is continued overnight. After addition of water extraction is carried out with ethyl acetate. The title compound is obtained from the combined organic phases after drying over sodium sulphate and evaporating-off of the solvent in a vacuum (JOC 1997, 62, 19, 6692-6696).