반응 #40330

반응 방정식

8-(4-fluor-phenyl)-1,4-dioxaspiro[4.5]decane

sulphuric acid

→

raw title compound

4-(4-fluorophenyl)-cyclohexanone

용매

dioxane

반응 조건

후처리

1. 1
   추출After dilution with water (12 ml) extraction

실험 절차

8-(4-fluor-phenyl)-1,4-dioxaspiro[4.5]decane (2 mmol) is dissolved in dioxane (6.5 ml) and treated with 3 ml 50% aqueous sulphuric acid accompanied by stirring at room temperature for 5 hours. After dilution with water (12 ml) extraction is carried out twice with dichloromethane. The raw title compound is obtained from the combined organic phases after drying over sodium sulphate and evaporating-off of the solvent in a vacuum (Tetrahedron 1998, 54, 15509-15524): tR 3.44 min (LC-1); ESI-MS(+): m/z 193.29 [M+H]+.

출처