반응 #40297

반응 방정식

2-imino-4-thiobiuret

2-bromo-4-isopropyl-cyclohexanone

ethyl acetate

→

rac. N-(6-isopropyl-4,5,6,7-tetrahydro-benzothiazole-2-yl)-guanidine

용매

ethanol

반응 조건

후처리

1. 1
   온도the reaction mixture is then refluxed for 16 hours
2. 2
   기타the precipitated-out product is isolated
3. 3
   여과by filtering off

실험 절차

2-imino-4-thiobiuret (5 mmol) is added accompanied by stirring to a solution of 2-bromo-4-isopropyl-cyclohexanone (5 mmol) in ethanol (10 ml) and the reaction mixture is then refluxed for 16 hours. After evaporating-off of the solvent ethyl acetate is added to the residue and the precipitated-out product is isolated by filtering off: tR 2.75 min (LC-1, one peak); ESI-MS (+/−): m/z 239.25 [M+H]+/237.24 [M−H]−.

출처