반응 #40295

반응 방정식

compound

(2R)—N-tert-Butoxycarbonyl-3-trimethylsilylalanine

Trimethylsilyl chloride

→

(2R)-3-Trimethylsilylalanine methyl ester hydrochloride

용매

methanol

반응 조건

후처리

1. 1
   온도the mixture is warmed to RT overnight
2. 2
   기타The volatile components are removed on a Rotavapor and subsequently under high vacuum
3. 3
   기타The target compound (224 mg, 92% of th.) is obtained

실험 절차

The compound of Example 6A (300 mg) is dissolved in methanol (3 ml) and cooled to 0° C. Trimethylsilyl chloride (590 mg, 4.7 eq.) is added dropwise in the course of 30 min. and the mixture is warmed to RT overnight. The volatile components are removed on a Rotavapor and subsequently under high vacuum. The target compound (224 mg, 92% of th.) is obtained.

출처