반응 #4027

반응 방정식

2-(p-methoxyphenyl)-5-octylpyridine

hydrobromic acid

water

→

2-(p-hydroxyphenyl)-5-octylpyridine

용매

acetic acid

반응 조건

후처리

1. 1
   온도the solution was heated for 15 hours
2. 2
   온도under reflux
3. 3
   추출the organic layer was extracted with chloroform
4. 4
   세척After washing the
5. 5
   추출extract three times with water
6. 6
   기타the chloroform was removed by distillation
7. 7
   기타The residue was recrystallized from a mixture of acetone and hexane

실험 절차

The 2-(p-methoxyphenyl)-5-octylpyridine was dissolved in 100 ml of acetic acid. 8 ml of 48% hydrobromic acid was added to the reaction solution and the solution was heated for 15 hours under reflux. 100 ml of water was added to the reaction solution and the organic layer was extracted with chloroform. After washing the extract three times with water, the chloroform was removed by distillation. The residue was recrystallized from a mixture of acetone and hexane to yield 8.3 g (0.029 mol) of 2-(p-hydroxyphenyl)-5-octylpyridine.

출처