반응 #4017

반응 방정식

2-chloro-1,1,1-triethoxyethane

2-aminothiophenol

→

2-chloromethylbenzothiazole

수율 91.3%

용매

methylene chloride

반응 조건

후처리

1. 1
   세척the resulting solution was washed with 3N HCl (10 ml)
2. 2
   기타The organic portion was evaporated
3. 3
   기타the residue chromatographed over silica gel

실험 절차

A solution of 2-chloro-1,1,1-triethoxyethane (5.9 g) and 2-aminothiophenol (2.5 g) was heated at 80° C. for 15 minutes. After cooling to room temperature, it was dissovled in methylene chloride (30 ml) and the resulting solution was washed with 3N HCl (10 ml) and then with water (20 ml). The organic portion was evaporated and the residue chromatographed over silica gel to obtain 2-chloromethylbenzothiazole (3.35 g; 90% yield), m.p. 34° C.

출처