반응 #3985

반응 방정식

4-Amino-1-(naphth-2-ylmethyl)piperidine

benzoylisothiocyanate

→

1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]thiourea

용매

toluene

반응 조건

후처리

1. 1
   기타The solvent was evaporated
2. 2
   workup.DISSOLUTIONthe gum dissolved in isopropyl alcohol
3. 3
   기타The solvent was evaporated
4. 4
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
5. 5
   기타The title compound crystallised
6. 6
   여과was filtered
7. 7
   건조dried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

실험 절차

4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoylisothiocyanate (0.69 g, 0.0042 m) in toluene (120 cm3) was stirred at room temperature for 6 hours. The solvent was evaporated and the gum dissolved in isopropyl alcohol and acidified with ethanolic HCl. The solvent was evaporated and the residue dissolved in ethyl acetate. The title compound crystallised and was filtered and dried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

출처