반응 #3968

반응 방정식

2-[2-methoxy-5-nitro-4-(4,4-dimethyl-7-nitro-2H,4H-isoquinolin-1,3-dione-2-yl)-phenyl]-5-methoxy-imidazo[4,5-b]pyridine

hydrazine hydrate

→

2-(2-Methoxy-4-amino-5-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

용매

isopropanol

반응 조건

후처리

1. 1
   온도refluxed for 1.75 hours
2. 2
   농축The reaction mixture is concentrated by evaporation
3. 3
   기타the residue is triturated with 50 ml of ice water
4. 4
   기타the product precipitated
5. 5
   기타is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:2)]

실험 절차

One half gram of 2-[2-methoxy-5-nitro-4-(4,4-dimethyl-7-nitro-2H,4H-isoquinolin-1,3-dione-2-yl)-phenyl]-5-methoxy-imidazo[4,5-b]pyridine is suspended in 10 ml of isopropanol, mixed with 0.5 ml of 80% hydrazine hydrate, and refluxed for 1.75 hours with stirring. The reaction mixture is concentrated by evaporation, the residue is triturated with 50 ml of ice water, and the product precipitated is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:2)].

출처