반응 #3963

반응 방정식

water

2-(2-dimethylamino-4-nitro-phenyl)-4H-imidazo[4,5-b]pyridin-5-one

hydrogen

hydrochloric acid

→

2-(2-Dimethylamino-4-amino-phenyl)-4H-imidazo[4,5-b]-pyridin-5-one hydrochloride

용매

dimethylformamide

반응 조건

후처리

1. 1
   여과The mixture is filtered off from the catalyst
2. 2
   workup.ADDITIONthe mother liquor is mixed with 100 ml each of ether and of ethyl acetate, and finally 3 ml of etheral hydrochloric acid
3. 3
   workup.ADDITIONare added
4. 4
   기타The precipitate is recrystallized from methanol
5. 5
   건조After drying over phosphorus pentoxide and potassium hydroxide
6. 6
   기타a product is obtained which

실험 절차

An amount of 1.7 gm of 2-(2-dimethylamino-4-nitro-phenyl)-4H-imidazo[4,5-b]pyridin-5-one is dissolved in 20 ml of dimethylformamide and mixed with 0.2 gm of 10% palladium/charcoal. The mixture is hydrogenated for three hours with hydrogen at ambient temperature under 5 bars of pressure. The mixture is filtered off from the catalyst, the mother liquor is mixed with 100 ml each of ether and of ethyl acetate, and finally 3 ml of etheral hydrochloric acid are added. The precipitate is recrystallized from methanol. After drying over phosphorus pentoxide and potassium hydroxide, a product is obtained which contains 1.5 mol of hydrochloric acid and 0.5 mol of water to 1 mol of base.

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