반응 #3958

반응 방정식

4-amino-5-(2-methoxy-4-methylmercapto-benzoylamino)-pyrimidin-2,6-dione

sodium hydroxide

→

crude product

8-(2-Methoxy-4-methylmercapto-phenyl)-purin-2,6-dione

용매

ethanol

반응 조건

후처리

1. 1
   기타a solution is formed
2. 2
   온도After cooling
3. 3
   여과filtered with glacial acetic acid
4. 4
   세척washed with water
5. 5
   기타dried at 70° C. in a circulating air drier

실험 절차

Two grams of 4-amino-5-(2-methoxy-4-methylmercapto-benzoylamino)-pyrimidin-2,6-dione are refluxed for 21 hours with 50 ml of ethanol and 50 ml of 2N sodium hydroxide solution. After about 15 minutes, a solution is formed. After cooling, the solution is suction filtered with glacial acetic acid, washed with water, and dried at 70° C. in a circulating air drier. The crude product thus obtained is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (19:1, 9:1, 4:1 and ethanol)].

출처