반응 #3934

반응 방정식

4-(4-chlorophenyl)butyl piperazine

1-bromo-3-chloropropane

potassium hydroxide

→

1-[4-(4-chlorophenyl)butyl]-4-(3-chloropropyl)piperazine dihydrochloride

수율 125.7%

용매

dimethyl sulfoxide

반응 조건

실험 절차

The procedure described in Example 1(a) was followed, using 10.0 g of 4-(4-chlorophenyl)butyl piperazine, 47.2 g of 1-bromo-3-chloropropane, 150 ml of dimethyl sulfoxide and 11.2 g of potassium hydroxide, to give 10.0 g (82% of theory) of 1-[4-(4-chlorophenyl)butyl]-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid, M.p. 266°-268° C.

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