반응 #3928

반응 방정식

1-(4-chlorobenzyl)piperazine

1-bromo-2-chloroethane

→

1-(4-chlorobenzyl)-4-(2-chloroethyl)piperazine dihydrochloride

수율 112.0%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   온도was refluxed for 8 hours
2. 2
   기타The solvent was removed in vacuo, and 2N sodium hydroxide
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   추출The product was extracted with methylene chloride
5. 5
   건조the extract was dried (sodium sulfate)
6. 6
   농축concentrated
7. 7
   기타The salt was precipitated with ethereal hydrochloric acid

실험 절차

A mixture of 15.0 g of 1-(4-chlorobenzyl)piperazine, 14.4 g of 1-bromo-2-chloroethane and 150 ml of tetrahydrofuran was refluxed for 8 hours. The solvent was removed in vacuo, and 2N sodium hydroxide was added to the residue. The product was extracted with methylene chloride, and the extract was dried (sodium sulfate) and concentrated. The salt was precipitated with ethereal hydrochloric acid to give 13.8 g (56% of theory) of 1-(4-chlorobenzyl)-4-(2-chloroethyl)piperazine dihydrochloride as a white crystalline solid.

출처