반응 #3915

반응 방정식

thiourea

sodium hydroxide

triethylamine

1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride

→

3-[4-(4-chlorophenethyl)piperazin-1-yl]propanethiol dihydrochloride

수율 176.1%

용매

water

ethanol

반응 조건

실험 절차

The procedure described in Example 1(b) was followed, using 1.3 g of thiourea, 6.4 g of 1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride, 1.6 g of triethylamine and 150 ml of reagent ethanol. The hydrolysis was effected with 3.5 g of sodium hydroxide and 40 ml of water. Work-up, as described above, gave 5.6 g (89% of theory) of 3-[4-(4-chlorophenethyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 279°-281° C.

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