반응 #3913

반응 방정식

phenyl isocyanate

3-(4-phenethylpiperazin-1-yl)propanethiol dihydrochloride

triethylamine

→

N-phenyl-S-[3-(4-phenethylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride monohydrate

수율 67.9%

용매

methylene chloride

반응 조건

실험 절차

The procedure described in Example 2 was followed, using 1.4 g of phenyl isocyanate, 4.0 g of 3-(4-phenethylpiperazin-1-yl)propanethiol dihydrochloride, 2.4 g of triethylamine and 50 ml of methylene chloride, to give 1.9 g (35% of theory) of N-phenyl-S-[3-(4-phenethylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride monohydrate as a white crystalline solid, M.p. 272°-275° C.

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