반응 #3904

반응 방정식

thiourea

sodium hydroxide

triethylamine

1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride

→

3-[4-(4-methylbenzyl)piperazin-1-yl]propanethiol dihydrochloride

수율 72.0%

용매

water

ethanol

반응 조건

실험 절차

The procedure described in Example 1(b) was followed, using 7.7 g of thiourea, 23.0 g of 1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride, 6.5 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 6.0 g of sodium hydroxide in 40 ml of water. Work-up, as described above, gave 16.4 g (72% of theory) of 3-[4-(4-methylbenzyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 273°-277° C. (dec.).

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