반응 #3903

반응 방정식

1-bromo-3-chloropropane

1-(4-methylbenzyl)piperazine

potassium hydroxide

dimethyl sulfoxide

→

1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride

용매

Water

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture was stirred for an additional hour
2. 2
   추출the product was extracted with ether
3. 3
   건조the extract was dried (sodium sulfate)
4. 4
   workup.ADDITIONtreated with ethereal hydrochloric acid

실험 절차

A mixture of 14.0 g of 1-(4-methylbenzyl)piperazine, 8.0 g of potassium hydroxide and 125 ml of dimethyl sulfoxide was stirred for 45 minutes. 11.8 g of 1-bromo-3-chloropropane were then added, and the mixture was stirred for an additional hour. Water was added, and the product was extracted with ether, and the extract was dried (sodium sulfate) and treated with ethereal hydrochloric acid to give 23.3 g (94% of theory) of 1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

출처