반응 #3888

반응 방정식

1-(4-chlorobenzyl)piperazine

potassium hydroxide

1-bromo-3-chloropropane

→

1-(4-chlorobenzyl)-4-(3-chloropropyl)piperazine dihydrochloride

수율 74.0%

용매

dimethyl sulfoxide

반응 조건

실험 절차

Utilizing the procedure described in Example 1(a), 20.0 g of 1-(4-chlorobenzyl)piperazine, 100 ml of dimethyl sulfoxide, 15.0 g of potassium hydroxide and 15.0 of 1-bromo-3-chloropropane yielded 25.1 g (74% of theory) of 1-(4-chlorobenzyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

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