반응 #3887

반응 방정식

phenyl isocyanate

3-(4-benzylpiperazin-1-yl)propanethiol dihydrochloride

triethylamine

→

N-phenyl-S-[3-(4-benzylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride monohydrate

수율 41.9%

용매

methylene chloride

반응 조건

후처리

1. 1
   온도The mixture was refluxed for four hours
2. 2
   세척washed with water
3. 3
   건조dried (sodium sulfate)
4. 4
   기타Precipitation of the salt with ethereal hydrochloric acid

실험 절차

1.6 g of phenyl isocyanate were added to a solution of 4.0 g of 3-(4-benzylpiperazin-1-yl)propanethiol dihydrochloride and 2.6 g of triethylamine in 50 ml of methylene chloride. The mixture was refluxed for four hours, washed with water and dried (sodium sulfate). Precipitation of the salt with ethereal hydrochloric acid gave 1.2 g (20% of theory) of N-phenyl-S-[3-(4-benzylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride monohydrate as a white crystalline solid, M.p. 216°-219° C.

출처