반응 #3880

반응 방정식

title compound

t-butoxycarbonyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide

hydrogen chloride dioxane

→

title compound

N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide monohydrochloride

용매

dioxane

반응 조건

후처리

1. 1
   농축After about 30 min. the solution was concentrated in vacuo to dryness
2. 2
   기타the residue triturated thoroughly with diethyl ether
3. 3
   기타The solid was collected
4. 4
   세척washed well with diethyl ether

실험 절차

To a solution of the title compound of Example 2 (43.1 g, 0.11 mole) in 100 ml of dioxane was added 100 ml of 6M hydrogen chloride/dioxane. After about 30 min. the solution was concentrated in vacuo to dryness and the residue triturated thoroughly with diethyl ether. The solid was collected and washed well with diethyl ether, giving 34.7 g of the title compound, which was used in subsequent reactions without further purification.

출처