반응 #3872

반응 방정식

potassium hydroxide

7-hydroxy-3-piperidino-2,2-dimethylbenzofuran

1,4-dibromobutane

→

desired product

7-(4-Bromobutoxy)-3-piperidino-2,2-dimethylbenzofuran

용매

ether

ether

반응 조건

후처리

1. 1
   세척washed with water
2. 2
   추출extracted with 5% aq. HCl
3. 3
   세척the acidic phase washed with ether
4. 4
   기타The acidic phase is made basic thereby forming an oil which
5. 5
   세척washed with sat'd aq. NaCl
6. 6
   기타dried
7. 7
   여과filtered
8. 8
   기타evaporated in vacuo

실험 절차

Crushed potassium hydroxide (19.6 g) and tetrabutyl ammonium chloride (1.7 g) are added to a solution of 7-hydroxy-3-piperidino-2,2-dimethylbenzofuran (14.4 g) in 1,4-dibromobutane (69.4 ml) and the mixture stirred at RT under nitrogen for 5 hours. The reaction mixture is diluted with ether, washed with water, extracted with 5% aq. HCl and the acidic phase washed with ether. The acidic phase is made basic thereby forming an oil which is taken up in ether, washed with sat'd aq. NaCl, dried, filtered and evaporated in vacuo affording the desired product as a liquid.

출처