반응 #3864

반응 방정식

potassium hydroxide

product

6-Hydroxy-4-piperidino-2,3-dihydrobenzopyran

1,3-dibromopropane

→

desired product

6-(3-Bromopropoxy)-4-piperidino-2,3-dihydrobenzopyran

용매

ether

diethyl ether

반응 조건

후처리

1. 1
   세척washed with water
2. 2
   추출extracted into 5% aq. HCl
3. 3
   세척The aqueous solution is washed with ether
4. 4
   기타yielding a yellow oil which
5. 5
   세척washed
6. 6
   기타dried
7. 7
   여과filtered
8. 8
   기타evaporated

실험 절차

Crushed potassium hydroxide (1.15 g) and tetrabutyl ammonium chloride (0.61 g) are added to a solution of the product obtained in Step 3. (4.8 g) in 1,3-dibromopropane (21 ml). The reaction mixture is stirred under nitrogen at RT for 48 hours, diluted with diethyl ether, washed with water and extracted into 5% aq. HCl. The aqueous solution is washed with ether and made alkaline yielding a yellow oil which is taken up in ether, washed, dried, filtered and evaporated to give the desired product as an oil.

출처