반응 #3802

반응 방정식

2-{2-[2-(1,4-bis-tert-butoxycarbonyl-butylcarbamoyl)phenyldisulfanyl]-benzoylamino}-hexanedioic acid di-tert-butyl ester

trifluoroacetic acid

anisole

→

title compound

2-{2-[2-(1,4-Dicarboxy-butylcarbamoyl)-phenyldisulfanyl]-benzoylamino}-hexanedioic acid

용매

dichloromethane

반응 조건

후처리

1. 1
   기타This compound was prepared
2. 2
   기타The crude product was recrystallized from methanol/dimethylformamide/water

실험 절차

This compound was prepared according to the procedure described in Example 50 using [S-(R*,R*)]-2-{2-[2-(1,4-bis-tert-butoxycarbonyl-butylcarbamoyl)phenyldisulfanyl]-benzoylamino}-hexanedioic acid di-tert-butyl ester (1.1 g, 1.4 mmol) from Example 10 mL dichloromethane, 10 mL trifluoroacetic acid, and 1 mL anisole. The crude product was recrystallized from methanol/dimethylformamide/water to afford 0.6 of the title compound, mp 259°-260° C.

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