반응 #379

반응 방정식

COC(=O)c1ccc(I)cc1O

CC(C)(C)OC(=O)N1CCNC

→

COC(=O)c1ccc(N2CCN(C

용매

COCCOC

반응 조건

실험 절차

tert-butyl piperazine-1-carboxylate (0.670 g, 3.60 mmol) and methyl 2-hydroxy-4-iodobenzoate (1 g, 3.60 mmol), BINAP (0.224 g, 0.36 mmol), cesium carbonate (2.461 g, 7.55 mmol) were put inDME (18 mL), tris(dibenzylideneacetone)dipalladium(0) (0.165 g, 0.18 mmol) was added last. Reaction wsa purged by nitrogen, and heated at90 °C overnight. No desired product was found.

출처