반응 #3781

반응 방정식

Triphenylphosphine ethylbromide

sodium hydride dimethyl sulfoxide

4,6-dimethoxy-2-hydroxybenzaldehyde

→

3,5-dimethoxy-2-propylphenol

수율 46.4%

반응 조건

후처리

1. 1
   기타at 50° C.
2. 2
   기타overnight
3. 3
   기타After the termination of the reaction
4. 4
   기타the resulting solution was partitioned with ethyl acetate and dilute hydrochloric acid
5. 5
   세척the resulting ethyl acetate phase was washed in water and subsequently in a saturated sodium chloride solution
6. 6
   건조dried over anhydrous magnesium sulfate
7. 7
   workup.DISTILLATIONto distill off the solvents under reduced pressure
8. 8
   기타The residue was purified by silica gel column chromatography (developing solvent: hexane:ethyl acetate=3:1)
9. 9
   workup.ADDITIONfollowed by addition of a catalytic amount of platinum dioxide for hydrogenation

실험 절차

Triphenylphosphine ethylbromide (4.1 g) was added to a 2N sodium hydride/dimethyl sulfoxide solution (11 ml), prior to agitation at 50° C. for 30 minutes. To the mixture was added 4,6-dimethoxy-2-hydroxybenzaldehyde (1 g), for agitation at 50° C. overnight. After the termination of the reaction, the resulting solution was partitioned with ethyl acetate and dilute hydrochloric acid, and the resulting ethyl acetate phase was washed in water and subsequently in a saturated sodium chloride solution and dried over anhydrous magnesium sulfate, to distill off the solvents under reduced pressure. The residue was purified by silica gel column chromatography (developing solvent: hexane:ethyl acetate=3:1), followed by addition of a catalytic amount of platinum dioxide for hydrogenation, to recover 3,5-dimethoxy-2-propylphenol (0.5 g; yield of 46%). By 1H-NMR (90 MHz, CDCl3), the compound has the peaks shown below.

출처