반응 #3763

반응 방정식

isobutyryl chloride

p-iodoaniline

pyridine

water

Isobutyryl chloride

→

N-(4-iodophenyl)isobutyramide

수율 97.4%

용매

acetonitrile

반응 조건

후처리

1. 1
   여과Precipitated crystalline solids were collected by filtration

실험 절차

To a dispersion of p-iodoaniline (219.0 g, 1 mol) in acetonitrile(1000 ml) was added pyridine (81.0 ml, 1 mol). Isobutyryl chloride (100.5 ml, 1 mol) was added dropwise to the mixture over 1 hour in an ice bath. The mixture was further stirred for one hour following the addition of isobutyryl chloride and to the mixture was added water (3000 ml). Precipitated crystalline solids were collected by filtration to give N-(4-iodophenyl)isobutyramide (281.7 g, Yield: 97%).

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