반응 #3740

반응 방정식

2-amino-2-cyanoacetamide

trimethylorthoformate

n-Propylamine

→

title compound

수율 61.1%

5-Amino-1-n-propylimidazole-4-carboxamide

수율 61.1%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 0.75 hour
3. 3
   온도to cool
4. 4
   기타The solid which precipitated
5. 5
   여과was collected by filtration
6. 6
   기타crystallised from methanol

실험 절차

A mixture of 2-amino-2-cyanoacetamide (2.8 g, 0.0282 mol), trimethylorthoformate (3.4 g, 0.0321 mol) and acetonitrile (55 ml) was heated under reflux for 0.75 hour, then allowed to cool. n-Propylamine (1.8 g, 0.0305 mol) was then added dropwise, and the resulting mixture stirred at ambient temperature for 36 hours. The solid which precipitated was collected by filtration and crystallised from methanol to give the title compound as a colourless solid (2.9 g, 61%), m.p. 241°-243° C. Found: C,49.67; H,7.15; N,33.64. C7 H12N4O requires C,49.98; H,7.19; N,33.31%.

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