반응 #3733

반응 방정식

1,3-Di-n-butyl-8-bromo xanthine

piperidine

→

title product

1,3-Di-n-butyl-8-piperidino Xanthine

용매

toluene

반응 조건

후처리

1. 1
   온도was refluxed for 9 hours
2. 2
   추출The reaction mixture was then extracted with water (4×30 ml)
3. 3
   건조the organic layer dried over anhydrous sodium sulphate
4. 4
   기타the solvent removed in vacuo
5. 5
   기타The residue was recrystallised from ethanol

실험 절차

1,3-Di-n-butyl-8-bromo xanthine (2 g, 0.0029 mol) was dissolved in toluene (50 ml). After addition of piperidine (5 g, 0.0058 mol) the mixture was refluxed for 9 hours. The reaction mixture was then extracted with water (4×30 ml), the organic layer dried over anhydrous sodium sulphate and the solvent removed in vacuo. The residue was recrystallised from ethanol to give the title product, yield 0.4 g (20%), m.pt. 221° C.

출처