반응 #3714

반응 방정식

(2RS,5RS)-2-dimethylaminomethyl-5-trifluoromethyl-cyclohexanone

3-trifluoromethyl-cyclohexanone

dimethylaminomethylene chloride

→

( 27 )

(1RS,2RS ,5RS)-3-(2-dimethylaminomethyl-1-hydroxy-5-trifluoromethyl-cyclohexyl)-phenol hydrochloride

용매

acetonitrile

반응 조건

후처리

1. 1
   기타The 5-epimer (27) of compound (25) was prepared, under the conditions

실험 절차

The 5-epimer (27) of compound (25) was prepared, under the conditions given in Example 27, from (2RS,5RS)-2-dimethylaminomethyl-5-trifluoromethyl-cyclohexanone, prepared from 3-trifluoromethyl-cyclohexanone and dimethylaminomethylene chloride in acetonitrile. (27) was obtained in a yield of 27% theoretical and had a melting point of 221°-223° C.

출처