반응 #367983

반응 방정식

2-aminopyrimidine

2-methoxycarbonylbenzenesulfonylisocyanate

→

desired compound

수율 65.7%

N-[(Pyrimidin-2-yl)aminocarbonyl]-2-methoxycarbonylbenzenesulfonamide

수율 65.7%

용매

acetonitrile

반응 조건

후처리

1. 1
   workup.STIRRINGAfter stirring that mixture for 24 hours
2. 2
   여과the resultant precipitate was filtered off

실험 절차

With stirring at ambient temperature, 1.0 g of 2-aminopyrimidine in 25 ml of anhydrous acetonitrile was added to 2.4 g of 2-methoxycarbonylbenzenesulfonylisocyanate. After stirring that mixture for 24 hours, the resultant precipitate was filtered off to yield 2.2 g of the desired compound which melted at 188°-192°. Its showing infrared absorption peaks at 1700, 1680 and 1580 cm-1 is consistent for N-[(pyrimidin-2-yl)aminocarbonyl]-2-methoxycarbonylbenzenesulfonamide.

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