반응 #3678

반응 방정식

NaOH

10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

triethylamine

diphenylphosphinyl chloride

→

white solid

수율 96.4%

10-[4-[(Diphenylphosphinyl)amino]benzoyl]-10,11-dihydro-5H-pyrrolo-[2,1-c][1,4]benzodiazepine

수율 96.4%

용매

dichloromethane

반응 조건

후처리

1. 1
   추출The mixture is extracted with ethyl acetate
2. 2
   세척the extract washed with brine
3. 3
   건조dried (Na2SO4)
4. 4
   기타The solvent is removed
5. 5
   기타the residue triturated with ether-hexane

실험 절차

A mixture of 0.10 g of 10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine 0.060 g of triethylamine and 0.12 g of diphenylphosphinyl chloride in 2 ml of dichloromethane is stirred at room temperature for 2 hours and then 1N NaOH is added. The mixture is extracted with ethyl acetate and the extract washed with brine and dried (Na2SO4). The solvent is removed and the residue triturated with ether-hexane to give 0.16 g of a white solid.

출처