반응 #367507

반응 방정식

4-Methylbenzyl cyanide

lithium aluminium hydride

NaOH

water

water

→

2-(4-methylphenyl)ethanamine

수율 112.4%

용매

ether

ether

반응 조건

후처리

1. 1
   온도The solution was refluxed for 1 h at the end of addition
2. 2
   온도The reaction mixture was cooled
3. 3
   여과the reaction mixture filtered
4. 4
   세척the residue washed with chloroform
5. 5
   건조the combined solvents dried (MgSO4)
6. 6
   기타Evaporation

실험 절차

4-Methylbenzyl cyanide (10 g) in ether was added dropwise under nitrogen to lithium aluminium hydride (2.9 g) in ether. The solution was refluxed for 1 h at the end of addition. The reaction mixture was cooled, water (3 ml), 2N.NaOH (3 ml), and further water (9 ml) were added, the reaction mixture filtered, the residue washed with chloroform and the combined solvents dried (MgSO4). Evaporation gave 2-(4-methylphenyl)ethanamine (11.59 g).

출처